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Embryonic Stem Cells Cultured in Microfluidic Chambers Take Control of Their Fate by Producing Endogenous Signals Including LIF.

Stem cells (Dayton, Ohio) - 1 Jun 2016

Guild Joshua, Haque Amranul, Gheibi Pantea, Gao Yandong, Son Kyung Jin, Foster Elena, Dumont Sophie, Revzin Alexander

Abstract excerpt

It is important to understand the role played by endogenous signals in shaping stem cell fate decisions to develop better culture systems and to improve understanding of development processes. In this study, we describe the behavior of mouse embryonic stem cells (mESCs) inside microfluidic chambers (microchambers) operated under conditions of minimal perfusion. mESCs inside microchambers formed colonies and...

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Identifiers

PMID: 26865369
DOI: 10.1002/stem.2324

Genes

LIF
STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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