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Article

Morphogen and community effects determine cell fates in response to BMP4 signaling in human embryonic stem cells

1 Jan 2017

Abstract excerpt

Systematic investigation of morphogen signaling is hampered by the difficulty of disentangling endogenous signaling from experimentally applied ligands. Here, we grow hESCs in micropatterned colonies of 1-8 cells ('µColonies') to quantitatively investigate paracrine signaling and the response to external stimuli. We examine BMP4-mediated differentiation in µColonies and standard culture conditions and find that...

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PMID: 28760810
DOI: 10.1242/dev.153239

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