Article
Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities.
Nature communications - 12 Jan 2016
Chen Sisi, Bremer Andrew W, Scheideler Olivia J, Na Yun Suk, Todhunter Michael E, Hsiao Sonny, Bomdica Prithvi R, Maharbiz Michel M, Gartner Zev J, Schaffer David V
Abstract excerpt
Recreating heterotypic cell-cell interactions in vitro is key to dissecting the role of cellular communication during a variety of biological processes. This is especially relevant for stem cell niches, where neighbouring cells provide instructive inputs that govern cell fate decisions. To investigate the logic and dynamics of cell-cell signalling networks, we prepared heterotypic cell-cell interaction arrays...
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