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Article

FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis.

Atherosclerosis - 1 Sept 2015

Menghini Rossella, Casagrande Viviana, Cardellini Marina, Ballanti Marta, Davato Francesca, Cardolini Iris, Stoehr Robert, Fabrizi Marta, Morelli Monica, Anemona Lucia, Bernges Isabel, Schwedhelm Edzard, Ippoliti Arnaldo, Mauriello Alessandro, Böger Rainer H, Federici Massimo

Abstract excerpt

BACKGROUND AND AIMS: The O subfamily of forkhead (FoxO) 1 is a pivotal element in the regulation of endothelial activation. Compartmentalization and activity of FoxO1 is regulated by post translational modifications, but the implication in endothelial dysfunction and atherosclerosis remain controversial. Our aim was to identify FoxO1 related metabolic signatures in endothelial cells. METHODS AND RESULTS: Using...

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Source

Identifiers

PMID: 26226438
DOI: 10.1016/j.atherosclerosis.2015.07.026

Genes

ADA
DDAH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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