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Article

Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells.

Microvascular research - 1 Jan 2015

Mochin Maria T, Underwood Karen F, Cooper Brandon, McLenithan John C, Pierce Adam D, Nalvarte Cesar, Arbiser Jack, Karlsson Anna I, Moise Alexander R, Moskovitz Jackob, Passaniti Antonino

Abstract excerpt

Angiogenesis is regulated by hyperglycemic conditions, which can induce cellular stress responses, reactive oxygen species (ROS), and anti-oxidant defenses that modulate intracellular signaling to prevent oxidative damage. The RUNX2 DNA-binding transcription factor is activated by a glucose-mediated intracellular pathway, plays an important role in endothelial cell (EC) function and angiogenesis, and is a target...

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Share to Aldehyde Reductase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 1 Subunit

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Share to Human Umbilical Vein Endothelial Cells

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Source

Open in PubMed Open full text

Identifiers

PMID: 25283348
DOI: 10.1016/j.mvr.2014.09.008
PMCID: PMC4412363

Genes

RUNX2
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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