Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attenuated humoral responses in HLA-A*24-positive individuals at risk of type 1 diabetes.

Diabetologia - 1 Oct 2015

Ye Jody, Long Anna E, Pearson James A, Taylor Hazel, Bingley Polly J, Williams Alistair J K, Gillespie Kathleen M

Abstract excerpt

AIMS/HYPOTHESIS: The rate of progression from islet autoimmunity to clinical type 1 diabetes depends on the rate of beta cell destruction. The HLA-A*24 gene is associated with early diabetes onset, but previous studies have shown attenuated humoral responses to islet antigens in individuals with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to HLA-A Antigens

Share to Immunity, Humoral

Share to Polymorphism, Single Nucleotide

Share to Young Adult

Source

Identifiers

PMID: 26224099
DOI: 10.1007/s00125-015-3702-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26224099-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attenuated humoral responses in HLA-A*24-positive individuals at risk of type 1 diabetes.PMID 26224099Read ↗

Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes.Semantic proximity Read ↗

HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives of type 1 diabetic patients.Semantic proximity Read ↗

Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A*24 and -B*18 Is Restricted to Multiple Islet Autoantibody-Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles.Semantic proximity Read ↗

Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies.Semantic proximity Read ↗

Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children.Semantic proximity Read ↗

Twenty-Year Progression Rate to Clinical Onset According to Autoantibody Profile, Age, and HLA-DQ Genotype in a Registry-Based Group of Children and Adults With a First-Degree Relative With Type 1 DiabetesSemantic proximity Read ↗

The relationship between islet autoantibody status and the genetic risk of type 1 diabetes in adult-onset type 1 diabetes.Semantic proximity Read ↗

Characteristics of autoantibody-positive individuals without high-risk HLA-DR4-DQ8 or HLA-DR3-DQ2 haplotypes.Semantic proximity Read ↗

The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic variantsSemantic proximity Read ↗

Dynamics of Islet Autoantibodies During Prospective Follow-Up From Birth to Age 15 Years.Semantic proximity Read ↗

Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes.Semantic proximity Read ↗

Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.