Article
Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies.
Diabetes care - 1 Jun 2012
Yu Liping, Boulware David C, Beam Craig A, Hutton John C, Wenzlau Janet M, Greenbaum Carla J, Bingley Polly J, Krischer Jeffrey P, Sosenko Jay M, Skyler Jay S, Eisenbarth George S, Mahon Jeffrey L
Abstract excerpt
OBJECTIVE: We assessed diabetes risk associated with zinc transporter-8 antibodies (ZnT8A), islet cell antibodies (ICA), and HLA type and age in relatives of people with type 1 diabetes with the standard biochemical autoantibodies (BAA) to insulin (IAA), GAD65 (GAD65A), and/or insulinoma-associated protein 2 antigen (IA-2A). RESEARCH DESIGN AND METHODS: For this analysis, 2,256 relatives positive for at least one...
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