Article
Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A*24 and -B*18 Is Restricted to Multiple Islet Autoantibody-Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles.
Diabetes care - 1 May 2018
Balke Else M, Balti Eric V, Van der Auwera Bart, Weets Ilse, Costa Olivier, Demeester Simke, Abrams Pascale, Casteels Kristina, Coeckelberghs Marina, Tenoutasse Sylvie, Keymeulen Bart, Pipeleers Daniel G, Gorus Frans K
Abstract excerpt
OBJECTIVE: We investigated the effect of HLA class I risk alleles on disease progression in various phases of subclinical islet autoimmunity in first-degree relatives of patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: A registry-based group of siblings/offspring (aged 0-39 years) was monitored from single- to multiple-autoantibody positivity (n = 267) and from multiple-autoantibody positivity to...
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