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Article

The relationship between islet autoantibody status and the genetic risk of type 1 diabetes in adult-onset type 1 diabetes.

Diabetologia - 1 Feb 2023

Thomas Nicholas J, Walkey Helen C, Kaur Akaal, Misra Shivani, Oliver Nick S, Colclough Kevin, Weedon Michael N, Johnston Desmond G, Hattersley Andrew T, Patel Kashyap A

Abstract excerpt

AIMS/HYPOTHESIS: The reason for the observed lower rate of islet autoantibody positivity in clinician-diagnosed adult-onset vs childhood-onset type 1 diabetes is not known. We aimed to explore this by assessing the genetic risk of type 1 diabetes in autoantibody-negative and -positive children and adults. METHODS: We analysed GAD autoantibodies, insulinoma-2 antigen autoantibodies and zinc transporter-8...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36355183
DOI: 10.1007/s00125-022-05823-1
PMCID: PMC9807542

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