Article
Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen.
PloS one - 1 Jan 2015
Kolan Shrikant Shantilal, Lejon Kristina, Koskinen Holm Cecilia, Sulniute Rima, Lundberg Pernilla, Matozaki Takashi, Oldenborg Per-Arne
Abstract excerpt
B lymphocyte development occurs in the bone marrow, while final differentiation and maturation can occur in both the bone marrow and the spleen. Here we provide evidence that signal regulatory protein α (SIRPα), an Ig-superfamily ITIM-receptor expressed by myeloid but not by lymphoid cells, is involved in regulating B cell maturation. Lack of SIRPα signaling in adult SIRPα-mutant mice resulted in a reduced...
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