Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Premature replacement of μ with α immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation

28 Jan 2010

Abstract excerpt

Sequentially along B cell differentiation, the different classes of membrane Ig heavy chains associate with the Ig alpha/Ig beta heterodimer within the B cell receptor (BCR). Whether each Ig class conveys specific signals adapted to the corresponding differentiation stage remains debated. We investigated the impact of the forced expression of an IgA-class receptor throughout murine B cell differentiation by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20133609
DOI: 10.1073/pnas.0912393107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Premature replacement of μ with α immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturationPMID 20133609Read ↗

Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut.Semantic proximity Read ↗

Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development.Semantic proximity Read ↗

B Cell Progenitors Are Arrested in Maturation but Have Intact VDJ Recombination in the Absence of Ig-α and Ig-βSemantic proximity Read ↗

A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing.Semantic proximity Read ↗

A functional BCR in human IgA and IgM plasma cellsSemantic proximity Read ↗

Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape.Semantic proximity Read ↗

Novel B cell population producing functional IgG in the absence of membrane IgM expression.Semantic proximity Read ↗

Exploring the Role of Microbiota in the Limiting of B1 and MZ B-Cell Numbers by Naturally Secreted Immunoglobulins.Semantic proximity Read ↗

The B‐cell system of human mucosae and exocrine glandsSemantic proximity Read ↗

Autosomal recessive agammaglobulinemia: novel insights from mutations in Ig-beta.Semantic proximity Read ↗

Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function.Semantic proximity Read ↗

IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.