Article
Requirement of SIRPα for protective immunity against Leishmania major.
Biochemical and biophysical research communications - 22 Oct 2010
Morimoto Naoko, Murata Yoji, Motegi Sei-ichiro, Suzue Kazutomo, Saito Yasuyuki, Okazawa Hideki, Ohnishi Hiroshi, Kotani Takenori, Kusakari Shinya, Ishikawa Osamu, Matozaki Takashi
Abstract excerpt
Signal regulatory protein α (SIRPα) is a transmembrane protein that binds the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic region and is abundantly expressed on dendritic cells and macrophages. Wild-type (WT) C57BL/6 mice are known to be resistant to Leishmania major infection. We here found that C57BL/6 mice that express a mutant version of SIRPα lacking most of the cytoplasmic region...
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