Article

Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History Study

2025-04-10

Abstract excerpt

The impact of amyloid-β (Aβ) accumulation on regional brain atrophy in preclinical Alzheimer’s disease (AD), and its interaction with risk factors like sex and APOE -ε4 carriership, remains unclear. In this study, we examined these associations in a population of older adults without dementia and evaluated the potential of Aβ-PET for risk stratification. We included 1329 participants (56% female) with an age of...

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Literature Corpus work: 627cbdff-bf49-5180-bf41-d67b478d59b0
DOI: 10.1101/2025.04.09.25324824

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