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Article

Interaction of antibacterial compounds with RND eﬄux pumps in Pseudomonas aeruginosa

8 Jul 2015

Abstract excerpt

Pseudomonas aeruginosa infections are becoming increasingly difficult to treat due to intrinsic antibiotic resistance and the propensity of this pathogen to accumulate diverse resistance mechanisms. Hyperexpression of eﬄux pumps of the Resistance-Nodulation-Cell Division (RND)-type multidrug eﬄux pumps (e.g., MexAB-OprM), chromosomally encoded by mexAB-oprM, mexCD-oprJ, mexEF-oprN, and mexXY (-oprA) is often...

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PMID: 26217310
DOI: 10.3389/fmicb.2015.00660

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