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Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition

6 Oct 2023

Abstract excerpt

The Resistance-Nodulation-Division (RND) efflux pump superfamily is pervasive among Gram-negative pathogens and contributes extensively to clinical antibiotic resistance. The opportunistic pathogen Pseudomonas aeruginosa contains 12 RND-type efflux systems, with four contributing to resistance including MexXY-OprM which is uniquely able to export aminoglycosides. At the site of initial substrate recognition,...

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Antibiotic Resistance in Bacteria
Berberine and alkaloids research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39843773
DOI: 10.1038/s44259-023-00013-4

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