Article

In silico identification of quorum sensing inhibitors against LasR protein in a clinical isolate of multidrug resistant Pseudomonas aeruginosa DMC-27b

2024-01-12

Abstract excerpt

<h4>Background: </h4> Pseudomonas aeruginosa is an opportunistic pathogen that uses quorum-sensing (QS) and biofilm formation to subvert antibiotic therapy. Antibiotic resistance has led to a demand for alternative methods of treatment, and destabilizing the LasR-OdDHL binding with inhibitors offers a potential solution. <h4>Methods: </h4>: This study aimed to construct a homology model of the LasR protein using...

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Literature Corpus work: 5b9dfca1-3dc7-564c-b64f-a524bd03f2d9
DOI: 10.12688/f1000research.131728.1

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