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Article

Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells.

Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2015

Wu Bingbing, Wei Shunhui, Petersen Natalia, Ali Yusuf, Wang Xiaorui, Bacaj Taulant, Rorsman Patrik, Hong Wanjin, Südhof Thomas C, Han Weiping

Abstract excerpt

Glucose stimulates insulin secretion from β-cells by increasing intracellular Ca(2+). Ca(2+) then binds to synaptotagmin-7 as a major Ca(2+) sensor for exocytosis, triggering secretory granule fusion and insulin secretion. In type-2 diabetes, insulin secretion is impaired; this impairment is ameliorated by glucagon-like peptide-1 (GLP-1) or by GLP-1 receptor agonists, which improve glucose homeostasis. However,...

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Identifiers

PMID: 26216970
DOI: 10.1073/pnas.1513004112
PMCID: PMC4538675

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