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miR-7 Regulates GLP-1-Mediated Insulin Release by Targeting β-Arrestin 1

6 Jul 2020

Abstract excerpt

Glucagon-like peptide-1 (GLP-1) has been shown to potentiate glucose-stimulated insulin secretion binding GLP-1 receptor on pancreatic β cells. β-arrestin 1 (βARR1) is known to regulate the desensitization of GLP-1 receptor. Mounting evidence indicates that microRNAs (miRNAs, miRs) are fundamental in the regulation of β cell function and insulin release. However, the regulation of GLP-1/βARR1 pathways by miRs has...

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PMID: 32640511
DOI: 10.3390/cells9071621

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