Article
Structural and mechanistic insights into secretagogin-mediated exocytosis.
Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2020
Qin Jiao, Liu Qi, Liu Zhe, Pan Yun-Zu, Sifuentes-Dominguez Luis, Stepien Karolina P, Wang Yan, Tu Yingfeng, Tan Shuai, Wang Yuan, Sun Qingxiang, Mo Xianming, Rizo Josep, Burstein Ezra, Jia Da
Abstract excerpt
Secretagogin (SCGN) is a hexa-EF-hand protein that is highly expressed in the pancreas, brain, and gastrointestinal tract. SCGN is known to modulate regulated exocytosis in multiple cell lines and tissues; however, its exact functions and underlying mechanisms remain unclear. Here, we report that SCGN interacts with the plasma membrane SNARE SNAP-25, but not the assembled SNARE complex, in a Ca2+-dependent...
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