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Article

Cav1.2 and Cav1.3 are differentially coupled to glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion in the pancreatic beta-cell line INS-1.

The Journal of pharmacology and experimental therapeutics - 1 Nov 2009

Jacobo Sarah Melissa P, Guerra Marcy L, Hockerman Gregory H

Abstract excerpt

The incretin peptides, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), potentiate glucose-stimulated insulin secretion (GSIS) and beta-cell proliferation and differentiation. Ca(2+) influx via voltage-gated L-type Ca(2+) channels is required for GLP-1 and GIP potentiation of GSIS. We investigated the role of the L-type Ca(2+) channels Ca(v)1.2 and Ca(v)1.3 in mediating...

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Share to Calcium Channel Blockers
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 4,5-Diphosphate

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Source

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Identifiers

PMID: 19710366
DOI: 10.1124/jpet.109.158519
PMCID: PMC2775263

Genes

INS
GIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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