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Article

A Screen for Epigenetically Silenced microRNA Genes in Gastrointestinal Stromal Tumors

27 Jul 2015

Abstract excerpt

BACKGROUND: Dysregulation of microRNA (miRNA) has been implicated in gastrointestinal stromal tumors (GISTs) but the mechanism is not fully understood. In this study, we aimed to explore the involvement of epigenetic alteration of miRNA genes in GISTs. METHODS: GIST-T1 cells were treated with 5-aza-2'-deoxycytidine (5-aza-dC) and 4-phenylbutyric acid (PBA), after which miRNA expression profiles were analyzed...

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PMID: 26214687
DOI: 10.1371/journal.pone.0133754

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