Article
Localization- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co-expressed miRNAs located at 14q32.31.
The Journal of pathology - 1 Jan 2010
Haller Florian, von Heydebreck Anja, Zhang Jitao David, Gunawan Bastian, Langer Claus, Ramadori Giuliano, Wiemann Stefan, Sahin Ozgür
Abstract excerpt
The molecular biology and clinical behaviour of gastrointestinal stromal tumours (GISTs) are associated with their anatomical localization (stomach or intestine), and also with the mutation status of the receptor tyrosine kinases KIT and PDGFRA. Twelve GISTs were evaluated for differential miRNA expression signatures by use of microarrays representing 734 human miRNAs. Thirty-two miRNAs were found to be...
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