Article
Epigenetics in gastrointestinal stromal tumors: clinical implications and potential therapeutic perspectives.
Digestive diseases and sciences - 1 Nov 2013
Sioulas Athanasios D, Vasilatou Diamantina, Pappa Vasiliki, Dimitriadis George, Triantafyllou Konstantinos
Abstract excerpt
Gastrointestinal stromal tumors (GIST) represent the most common mesenchymal neoplasms affecting the gastrointestinal tract. Activating mutations in either the KIT or PDGFRa gene are the principal oncogenic triggers with the former accounting for more than 80 % of cases. In the small subset of GIST that are wild type for both the aforementioned changes, other germline or somatic mutations have been identified....
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