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Article

Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour

27 Jun 2011

Abstract excerpt

BACKGROUND AND AIMS: The majority of gastrointestinal stromal tumors (GISTs) have KIT mutations; however, epigenetic abnormalities that could conceivably potentiate the aggressiveness of GISTs are largely unidentified. Our aim was to establish epigenetic profiles associated with the malignant transformation of GISTs. METHODS: Methylation of four tumor suppressor genes, RASSF1A, p16, CDH1, and MGMT was analyzed in...

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PMID: 21708825
DOI: 10.1136/gut.2011.241034

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