Article
MicroRNAs and Gastrointestinal Stromal Tumor.
Advances in experimental medicine and biology - 1 Jan 2015
Akçakaya Pinar, Lui Weng-Onn
Abstract excerpt
Gastrointestinal stromal tumor (GIST) is the most commonly diagnosed mesenchymal tumor in the gastrointestinal tract. This tumor type is driven by gain-of-function mutations in receptor tyrosine kinases (such as KIT, PDGFRA, and BRAF) or loss-of-function mutations in succinate dehydrogenase complex subunit genes (SDHx). Molecular studies on GIST have improved our understanding of the biology of the disease and...
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