Article
miRNA Expression May Have Implications for Immunotherapy in PDGFRA Mutant GISTs.
International journal of molecular sciences - 14 Oct 2022
Ravegnini Gloria, Nannini Margherita, Indio Valentina, Serrano Cesar, Gorini Francesca, Astolfi Annalisa, Di Vito Aldo, Morroni Fabiana, Pantaleo Maria Abbondanza, Hrelia Patrizia, Angelini Sabrina
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) harboring mutations in the PDGFRA gene occur in only about 5-7% of patients. The most common PDGFRA mutation is exon 18 D842V, which is correlated with specific clinico-pathological features compared to the other PDGFRA mutated GISTs. Herein, we present a miRNA expression profile comparison of PDGFRA D842V mutant GISTs and PDGFRA with mutations other than D842V (non-D842V)....
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