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Article

Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's Sarcoma

1 Feb 2010

Abstract excerpt

ETS proteins are a family of transcription factors that play important roles in the development of cancer. The Ewing's sarcoma EWS/ETS fusion oncoproteins control a number of cancer-relevant phenotypes in that disease. We recently demonstrated that EWS/FLI, the most common EWS/ETS fusion in Ewing's sarcoma, regulates a portion of its target genes, including the critical target NR0B1, via GGAA-containing...

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PMID: 20827386
DOI: 10.1177/1947601910361495

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's SarcomaPMID 20827386Read ↗

Microsatellites are EWS/FLI response elements: genomic "junk" is EWS/FLI's treasure.Semantic proximity Read ↗

Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group.Semantic proximity Read ↗

Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growthSemantic proximity Read ↗

The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcomaSemantic proximity Read ↗

Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.Semantic proximity Read ↗

EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations.Semantic proximity Read ↗

Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding.Semantic proximity Read ↗

Downstream EWS/FLI1 - upstream Ewing's sarcomaSemantic proximity Read ↗

EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing SarcomaSemantic proximity Read ↗

The Drosophila FET orthologue Cabeza is an essential cofactor for ETV4-mediated activation of GGAA microsatellite neoenhancersSemantic proximity Read ↗

EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing SarcomaSemantic proximity Read ↗

A Molecular Function Map of Ewing's SarcomaSemantic proximity Read ↗

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