Article
Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.
Molecular psychiatry - 1 Nov 2016
Herold C, Hooli B V, Mullin K, Liu T, Roehr J T, Mattheisen M, Parrado A R, Bertram L, Lange C, Tanzi R E
Abstract excerpt
The genetic basis of Alzheimer's disease (AD) is complex and heterogeneous. Over 200 highly penetrant pathogenic variants in the genes APP, PSEN1, and PSEN2 cause a subset of early-onset familial AD. On the other hand, susceptibility to late-onset forms of AD (LOAD) is indisputably associated to the ɛ4 allele in the gene APOE, and more recently to variants in more than two-dozen additional genes identified in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.