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Article

Multi-scale biomechanical remodeling in aging and genetic mutant murine mitral valve leaflets: insights into Marfan syndrome.

PloS one - 1 Jan 2012

Gould Russell A, Sinha Ravi, Aziz Hamza, Rouf Rosanne, Dietz Harry C, Judge Daniel P, Butcher Jonathan

Abstract excerpt

Mitral valve degeneration is a key component of the pathophysiology of Marfan syndrome. The biomechanical consequences of aging and genetic mutation in mitral valves are poorly understood because of limited tools to study this in mouse models. Our aim was to determine the global biomechanical and...

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Identifiers

PMID: 22984535
DOI: 10.1371/journal.pone.0044639
PMCID: PMC3439411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22984535-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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