Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues.

doi:10.1002/jbmr.1751

Article

Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2013

Ehlen Harald W A, Chinenkova Milana, Moser Markus, Munter Hans-Markus, Krause Yvonne, Gross Stefanie, Brachvogel Bent, Wuelling Manuela, Kornak Uwe, Vortkamp Andrea

Abstract excerpt

During vertebrate skeletal development, osteoblasts produce a mineralized bone matrix by deposition of hydroxyapatite crystals in the extracellular matrix. Anoctamin6/Tmem16F (Ano6) belongs to a conserved family of transmembrane proteins with chloride channel properties. In addition, Ano6 has been linked to phosphatidylserine (PS) scrambling in the plasma membrane. During skeletogenesis, Ano6 mRNA is expressed in...

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Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues.

Abstract excerpt

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