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Article

Nintedanib Is a Highly Effective Therapeutic for Neuroendocrine Carcinoma of the Pancreas (PNET) in the Rip1Tag2 Transgenic Mouse Model.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2015

Bill Ruben, Fagiani Ernesta, Zumsteg Adrian, Antoniadis Helena, Johansson David, Haefliger Simon, Albrecht Imke, Hilberg Frank, Christofori Gerhard

Abstract excerpt

PURPOSE: Pancreatic neuroendocrine tumors (PNET) represent a rare but challenging heterogeneous group of cancers with an increasing incidence over the last number of decades. Herein, we report an in-depth evaluation of the new antiangiogenic small-molecule tyrosine kinase inhibitor (TKI) nintedanib in the preclinical Rip1Tag2 transgenic mouse model of neuroendocrine carcinoma of the pancreas (insulinoma)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Pathologic

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Source

Identifiers

PMID: 26206868
DOI: 10.1158/1078-0432.CCR-14-3036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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