Article
Establishment of a new human pancreatic cancer cell line, NOR-P1, with high angiogenic activity and metastatic potential.
Cancer letters - 31 Jul 2000
Sato N, Mizumoto K, Beppu K, Maehara N, Kusumoto M, Nabae T, Morisaki T, Katano M, Tanaka M
Abstract excerpt
We present here a new cell line, NOR-P1, established from a metastatic subcutaneous tumor of a patient with pancreatic cancer. The cells show rapid growth in culture with a doubling time of 16 h and high migration activity. Genetic and molecular analyses revealed high telomerase activity and a mutation in the K-ras oncogene. Of particular interest, the cells express markedly elevated mRNA levels of angiogenic...
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