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Article

Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity

11 Sept 2017

Abstract excerpt

Sustained angiogenesis is essential for the development of solid tumors and metastatic disease. Disruption of signaling pathways that govern tumor vascularity provide a potential avenue to thwart cancer progression. Through phage display-based functional proteomics, immunohistochemical analysis of human pancreatic ductal carcinoma (PDAC) specimens, and in vitro validation, we reveal that hornerin, an S100...

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PMID: 28916756
DOI: 10.1038/s41467-017-00488-6

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