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Article

decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary.

Cell - 24 Jul 1998

Xie T, Spradling A C

Abstract excerpt

Stem cells are thought to occupy special local environments, or niches, established by neighboring cells that give them the capability for self-renewal. Each ovariole in the Drosophila ovary contains two germline stem cells surrounded by a group of differentiated somatic cells that express hedgehog and wingless. Here we show that the BMP2/4 homolog decapentaplegic (dpp) is specifically required to maintain female...

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Source

Identifiers

PMID: 9695953
DOI: 10.1016/s0092-8674(00)81424-5

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary.PMID 9695953Read ↗

The Drosophila female germline stem cell lineage acts to spatially restrict DPP function within the niche.Semantic proximity Read ↗

Reduction of Cullin-2 in somatic cells disrupts differentiation of germline stem cells in the Drosophila ovary.Semantic proximity Read ↗

Somatic support cells restrict germline stem cell self-renewal and promote differentiation.Semantic proximity Read ↗

Ectopic activation of Dpp signalling in the male <i>Drosophila</i> germline inhibits germ cell differentiationSemantic proximity Read ↗

Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary.Semantic proximity Read ↗

An epithelial niche in the Drosophila ovary undergoes long-range stem cell replacement.Semantic proximity Read ↗

Drosophila's contribution to stem cell researchSemantic proximity Read ↗

Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling.Semantic proximity Read ↗

C. elegans germ cells divide and differentiate in a folded tissueSemantic proximity Read ↗

The Wnt pathway limits BMP signaling outside of the germline stem cell niche in Drosophila ovaries.Semantic proximity Read ↗

An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells.Semantic proximity Read ↗

Daughterless coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila.Semantic proximity Read ↗

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