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Article

Reduced cul-5 activity causes aberrant follicular morphogenesis and germ cell loss in Drosophila oogenesis.

PloS one - 4 Feb 2010

Kugler Jan-Michael, Lem Christopher, Lasko Paul

Abstract excerpt

Drosophila oogenesis is especially well suited for studying stem cell biology, cellular differentiation, and morphogenesis. The small modifier protein ubiquitin regulates many cellular pathways. Ubiquitin is conjugated to target proteins by a diverse class of enzymes called ubiquitin E3 ligases. Here we characterize the requirement of Cul-5, a key component of a subgroup of Cullin-RING-type ubiquitin E3 ligases,...

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Identifiers

PMID: 20140218
DOI: 10.1371/journal.pone.0009048
PMCID: PMC2816211

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Source receipt: pubmed, retrieved 7 Sept 2026.

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