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Type 2 alveolar cells are stem cells in adult lung

9 Jun 2013

Abstract excerpt

Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type 1 epithelial cells (AEC2s and AEC1s), capillaries, and various resident mesenchymal cells. Here, we use a combination of in vivo clonal lineage analysis, different injury/repair systems, and in vitro culture of purified cell populations to obtain new information about the contribution of AEC2s to alveolar maintenance and...

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PMID: 23921127
DOI: 10.1172/jci68782

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