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Article

Caffeine Cytochrome P450 1A2 Metabolic Phenotype Does Not Predict the Metabolism of Heterocyclic Aromatic Amines in Humans.

Chemical research in toxicology - 17 Aug 2015

Turesky Robert J, White Kami K, Wilkens Lynne R, Le Marchand Loïc

Abstract excerpt

2-Amino-1-methylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) are carcinogenic heterocyclic aromatic amines (HAAs) formed in well-done cooked meats. Chemicals that induce cytochrome P450 (P450) 1A2, a major enzyme involved in the bioactivation of HAAs, also form in cooked meat. Therefore, well-done cooked meat may pose an increase in cancer risk because it contains both...

Topics

Amines
Animals
Caffeine
Cattle
Chromatography, High Pressure Liquid
Cooking
Cytochrome P-450 CYP1A2
Eating
Female
Healthy Volunteers
Heterocyclic Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

High-Throughput Screening Assays

Humans

Male

Meat

Phenotype

Source

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Identifiers

PMID: 26203673
DOI: 10.1021/acs.chemrestox.5b00177
PMCID: PMC4571451

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