Article
Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2015
Amaravadi Ravi K, Hamilton Kathryn E, Ma Xiaohong, Piao Shengfu, Portillo Armando Del, Nathanson Katherine L, Carlino Matteo S, Long Georgina V, Puzanov Igor, Xu Xiaowei, Morrissette Jennifer J D, Tsai Kenneth Y, Flaherty Keith T, Sosman Jeffrey A, Goodman Grant R, McArthur Grant A, Rustgi Anil K, Metz David C, Schuchter Lynn M, Chapman Paul B, Sepulveda Antonia R
Abstract excerpt
PURPOSE: BRAF inhibitors (BRAFi) extend survival in BRAF-mutant melanoma but can promote the growth of Ras-mutant neoplasms. This study determined if gastrointestinal polyps found in BRAFi-treated patients harbored Ras mutations. EXPERIMENTAL DESIGN: Colonic and gastric polyps were identified and resected from BRAFi-treated melanoma patients. Next-generation sequencing (NGS) was performed on polyps. The ability...
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