Article
Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia.
Cancer research - 15 Nov 2002
Yuen Siu T, Davies Helen, Chan Tsun L, Ho Judy W, Bignell Graham R, Cox Charles, Stephens Philip, Edkins Sarah, Tsui Wendy W, Chan Annie S, Futreal P Andrew, Stratton Michael R, Wooster Richard, Leung Suet Y
Abstract excerpt
Activation of the RAS/RAF/extracellular signal-regulated kinase-mitogen-activated protein kinase/extracellular signal-regulated kinase/mitogen-activated protein kinase pathway by RAS mutations is commonly found in human cancers. Recently, we reported that mutation of BRAF provides an alternative route for activation of this signaling pathway and can be found in melanomas, colorectal cancers, and ovarian tumors....
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