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Article

A Case of Microsatellite Instability-High Colon Cancer in a Young Woman With Familial Adenomatous Polyposis.

Journal of the National Comprehensive Cancer Network : JNCCN - 1 Dec 2021

Blum Steven M, Jeck William R, Kipnis Lindsay, Bleday Ronald, Nowak Jonathan A, Yurgelun Matthew B

Abstract excerpt

Two major molecular pathways of colorectal carcinogenesis, chromosomal instability (CIN) and microsatellite instability (MSI), are considered to be mutually exclusive. Distinguishing CIN from MSI-high tumors has considerable therapeutic implications, because patients with MSI-high tumors can derive considerable benefit from immune checkpoint inhibitors, and tumors that evolved through the CIN pathway do not...

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Source

Identifiers

PMID: 34902833
DOI: 10.6004/jnccn.2021.7073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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