Article
Gene-based meta-analysis of genome-wide association study data identifies independent single-nucleotide polymorphisms in ANXA6 as being associated with systemic lupus erythematosus in Asian populations.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Nov 2015
Zhang Jing, Zhang Lu, Zhang Yan, Yang Jing, Guo Mengbiao, Sun Liangdan, Pan Hai-Feng, Hirankarn Nattiya, Ying Dingge, Zeng Shuai, Lee Tsz Leung, Lau Chak Sing, Chan Tak Mao, Leung Alexander Moon Ho, Mok Chi Chiu, Wong Sik Nin, Lee Ka Wing, Ho Marco Hok Kung, Lee Pamela Pui Wah, Chung Brian Hon-Yin, Chong Chun Yin, Wong Raymond Woon Sing, Mok Mo Yin, Wong Wilfred Hing Sang, Tong Kwok Lung, Tse Niko Kei Chiu, Li Xiang-Pei, Avihingsanon Yingyos, Rianthavorn Pornpimol, Deekajorndej Thavatchai, Suphapeetiporn Kanya, Shotelersuk Vorasuk, Ying Shirley King Yee, Fung Samuel Ka Shun, Lai Wai Ming, Garcia-Barceló Maria-Mercè, Cherny Stacey S, Sham Pak Chung, Cui Yong, Yang Sen, Ye Dong Qing, Zhang Xue-Jun, Lau Yu Lung, Yang Wanling
Abstract excerpt
OBJECTIVE: Previous genome-wide association studies (GWAS), which were mainly based on single-variant analysis, have identified many systemic lupus erythematosus (SLE) susceptibility loci. However, the genetic architecture of this complex disease is far from being understood. The aim of this study was to investigate whether using a gene-based analysis may help to identify novel loci, by considering global...
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