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Article

Gene-based association analysis identified a novel gene associated with systemic lupus erythematosus.

Annals of human genetics - 1 Nov 2021

Ding Xian, Cai Minglong, Wang Sun, Yang Qingqing, Zheng Xiaodong, Zuo Xianbo, Liu Shengxiu

Abstract excerpt

OBJECTIVE: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with strong genetic predisposition. Genome-wide association studies (GWAS) of SLE have identified more than 50 robust susceptibility loci. However, traditional individual SNP-based GWAS have made it difficult to identify variants with small effects. Moreover, variants revealed by GWAS only explain a limited disease heritability,...

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PMID: 34145571
DOI: 10.1111/ahg.12439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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