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Article

Genetic variability of genes in NER pathway influences the treatment outcome of gastric cancer.

International journal of clinical and experimental pathology - 1 Jan 2015

Xue Ming-Hui, Li Guang-Yan, Wu Xin-Jun, Zhang Chao-Xian, Zhang Cai-Feng, Zhu Kong-Xi

Abstract excerpt

We performed a study to investigate the role of ERCC1, ERCC2, ERCC5, XPA and XPC polymorphisms from perspective of the whole NER pathway in the prognosis of gastric cancer. A total of 410 gastric cancer patients were recruited between January 2010 and December 2011. Restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) was used to analyze genotypes of ERCC1 rs11615 and rs3212986, ERCC2...

Topics

Adult
Aged
Amplified Fragment Length Polymorphism Analysis
Biomarkers, Tumor
DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA-Binding Proteins

Disease Progression

Disease-Free Survival

Endonucleases

Female

Gene Frequency

Genetic Predisposition to Disease

Heterozygote

Homozygote

Humans

Kaplan-Meier Estimate

Logistic Models

Male

Source

Open in PubMed Open full text

Identifiers

PMID: 26191265
PMCID: PMC4503136

Genes

ERCC1
ERCC2
ERCC5
XPA
XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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