Article
A genetic variant in ERCC2 is associated with gastric cancer prognosis in a Chinese population.
Mutagenesis - 1 Jul 2013
Chu Haiyan, Gu Dongying, Xu Ming, Xu Zhi, Gong Yonglin, Gong Weida, Tang Yongfei, Zhou Jianwei, Tong Na, Zhang Zhengdong, Chen Jinfei, Wang Meilin
Abstract excerpt
Endogenous and exogenous factors can induce DNA damage, leading to increased risk of cancer. Nucleotide excision repair (NER) is considered as the most versatile DNA repair pathway to deal with a variety of different DNA lesions. ERCC1 and ERCC2 are the two important proteins in NER pathway. In this study, we investigated the association of three functional single nucleotide polymorphisms (SNPs) (ERCC1 rs11615,...
Topics
- Adult
- Aged
- Asian People
- China
- DNA-Binding Proteins
- Endonucleases
- Female
- Genetic Variation
- Genotype