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Functional genetic variants of XRCC4 and ERCC1 predict survival of gastric cancer patients treated with chemotherapy by regulating the gene expression.

Molecular carcinogenesis - 1 Dec 2017

Cheng Lei, Qiu Lixin, Wang Mengyun, Zhang Ruoxin, Sun Menghong, Zhu Xiaodong, Wang Yanong, Wei Qingyi

Abstract excerpt

DNA repair protects genomic integrity and may modulate chemotherapy efficacy. Few large-scale studies have evaluated predictive roles of genetic variants of DNA repair genes in survival of Chinese gastric cancer (GCa) patients treated with chemotherapy. Here, we assessed the roles of 35 single nucleotide polymorphisms (SNPs) in DNA repair genes in survival of 1002 GCa patients, of whom 694 received chemotherapy...

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Source

Identifiers

PMID: 28796378
DOI: 10.1002/mc.22713

Genes

ERCC1
XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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