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Article

Mutations leading to constitutive active gp130/JAK1/STAT3 pathway.

Cytokine & growth factor reviews - 1 Oct 2015

Pilati Camilla, Zucman-Rossi Jessica

Abstract excerpt

Constitutive activation of STAT (Signal Transducer and Activator of Transcription) transcription factors is a common feature identified in numerous tumors. Inflammatory hepatocellular adenomas (IHCA) are benign liver tumors characterized by an inflammatory phenotype and an overexpression of STAT3 target genes. Recurrent somatic mutations in major actors belonging to the IL6/JAK/STAT3 pathway have been identified...

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Share to Cytokine Receptor gp130
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26188635
DOI: 10.1016/j.cytogfr.2015.07.010

Genes

STAT3
JAK1
FRK
GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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