Article
Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation.
Cancer cell - 14 Apr 2014
Pilati Camilla, Letouzé Eric, Nault Jean-Charles, Imbeaud Sandrine, Boulai Anaïs, Calderaro Julien, Poussin Karine, Franconi Andrea, Couchy Gabrielle, Morcrette Guillaume, Mallet Maxime, Taouji Saïd, Balabaud Charles, Terris Benoit, Canal Frédéric, Paradis Valérie, Scoazec Jean-Yves, de Muret Anne, Guettier Catherine, Bioulac-Sage Paulette, Chevet Eric, Calvo Fabien, Zucman-Rossi Jessica
Abstract excerpt
Hepatocellular adenomas (HCA) are benign liver tumors predominantly developed in women using oral contraceptives. Here, exome sequencing identified recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation, and cell proliferation sensitive to Src inhibitors. We al...
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