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Article

GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation.

Journal of hepatology - 1 Jan 2012

Nault Jean Charles, Fabre Monique, Couchy Gabrielle, Pilati Camilla, Jeannot Emmanuelle, Tran Van Nhieu Jeanne, Saint-Paul Marie-Christine, De Muret Anne, Redon Marie-José, Buffet Catherine, Salenave Sylvie, Balabaud Charles, Prevot Sophie, Labrune Philippe, Bioulac-Sage Paulette, Scoazec Jean-Yves, Chanson Philippe, Zucman-Rossi Jessica

Abstract excerpt

BACKGROUND & AIMS: Mosaic G-protein alpha-subunit (GNAS)-activating mutations are responsible for the McCune-Albright (MCA) syndrome. This oncogene that activates the adenylate cyclase is also mutated in various tumor types leading to the accumulation of cyclic-AMP. Identification of a hepatocellular adenoma (HCA) in two MCA patients led us to search for GNAS activation in benign and malignant hepatocellular...

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Topics

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Share to Adenoma, Liver Cell
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromogranins

Share to DNA, Neoplasm

Share to Fibrous Dysplasia, Polyostotic

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Liver Neoplasms

Share to STAT3 Transcription Factor

Source

Identifiers

PMID: 21835143
DOI: 10.1016/j.jhep.2011.07.018

Genes

GNAS
STAT3
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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