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Article

Haplotype-based approach to known MS-associated regions increases the amount of explained risk.

Journal of medical genetics - 1 Sept 2015

Khankhanian Pouya, Gourraud Pierre-Antoine, Lizee Antoine, Goodin Douglas S

Abstract excerpt

Genome-wide association studies (GWAS), using single nucleotide polymorphisms (SNPs), have yielded 110 non-human leucocyte antigen genomic regions that are associated with multiple sclerosis (MS). Despite this large number of associations, however, only 28% of MS-heritability can currently be explained. Here we compare the use of multi-SNP-haplotypes to the use of single-SNPs as alternative methods to describe MS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26185143
DOI: 10.1136/jmedgenet-2015-103071
PMCID: PMC4552900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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