Article
Refining the results of a whole-genome screen based on 4666 microsatellite markers for defining predisposition factors for multiple sclerosis.
Electrophoresis - 1 Jul 2004
Gödde René, Nigmatova Viktoria, Jagiello Peter, Sindern Eckhart, Haupts Michael, Schimrigk Sebastian, Epplen Jörg T
Abstract excerpt
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with a complex genetic background. In order to identify loci associated with the disease, we had performed a genome screen initially using 6000 microsatellite markers in pooled DNA samples of 198 MS patients and 198 controls. Here, we report on the detailed reanalysis of this set of data. Distinctive features of microsatellites...
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